Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus

Mashhad University of Medical Sciences30 enrolled

Overview

Lichen planus (LP) is a common chronic inflammatory mucocutaneous disease with an immunologic etiology ,which has number of different clinical forms. Alternative natural or herbal origine drugs with antioxidant and anti-inflammatory properties have been used individually or in combination with systemic corticosteroids in order to decrease adverse drug reactions. This study was conducted to evaluate the effect of quercetin on treatment of erosive -atrophic lesions of oral lichen planus (OLP).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Atrophic Oral Lichen Planus Erosive Oral Lichen Planus

Interventions

The patient is directed to use placebo capsule two times a day, ,until the one mouth

QuercetinDRUG

The patient is directed to digest quercetin hydrate capsule two times a day,until one mouth

Eligibility

Sex: ALLMin age: 12 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * confirmation of clinical diagnosis of Atrophic and erosive lichen planus by histological examination * two weeks wash out periods after the last treatment * having the experience of atrophic and erosive lesion greater than 1 cm having the experience of pain and burning greater than 3.5 in VAS Score Exclusion Criteria: * confirmation of dysplasia and malignancy in histologic examination * confirmation of lichenoid reaction in histologic examination * pregnancy and breast feeding * using fluorokinolon and cyclosporin which interact with quercetin

Locations (1)

Mashhad university of Medical science, Research Center of oral and maxillofacial medicine

Mashhad, Khorasan Razavi, Iran

RECRUITING

Outcomes

Primary Outcomes

the effects of this Drug on OLP measured with VAS scale for pain and evaluation of intensity of lesions.

In the present work the Analogical Visual Scale is used TO evaluate pain,and we also record the intensity of lesions weekly and any side effect of this Drug

Time frame: 2 months

Central Contacts

maryam amirchaghmaghi, assistant professor

CONTACT

0098-0511889201 amirchakhmaghim@mums.ac.ir

Data from ClinicalTrials.gov

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