The use of dobutamine in postoperative hemodynamic treatment is widespread despite seemingly intact contraction of the heart. This study aims to elucidate the efficacy of low-dose dobutamine infusion in patients in the postoperative phase replacement of the aortic valve.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
10
90 minutes of infusion 5 ug/kg/minute followed by isotonic saline for the same duration. The sequence of the above is randomized
Department of Anaesthesia & Intensive Care, Århus University Hospital
Aarhus, Denmark
Cardiac output
Change in cardiac output (l/min) from initiation of study drug or placebo until 90 minutes of infusion.
Time frame: From 0 to 90 minutes after drug initiation
Mean pulmonary artery pressure
Changes in pulmonary artery pressure (mmHg) from start of study drug or placebo infusion until 90 minutes after the start.
Time frame: From 0 to 90 minutes after drug initiation.
Echocardiography
Echocardiographic measures of systolic and diastolic heart function.
Time frame: From 0 minutes to 90 minutes after drug initiation
Changes in mixed venous saturation
Changes in mixed venous saturation (in per cent) from baseline until the end of dobutrex or placebo infusion.
Time frame: From 0 minutes to 90 minutes after drug initiation
norepinephrine requirement
The amount of norepinephrinem(mg) required to maintain adequate systemic blood pressure during the infusion period of dobutrex and placebo
Time frame: From 0 minutes to 90 minutes after drug initiation
Central venous pressure
Changes in CVP from baseline until 90 minutes of study drug or placebo infusion.
Time frame: From 0 minutes to 90 minutes after drug initiation
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