Patients with chronic pain can experience considerable changes in their cognitive function such as forgetfulness, increased absentmindedness, confusion etc. Opioids (e.g. morphine and morphine-like analgesics) are often used in treatment of acute and chronic pain and can lead to worsening of the cognitive function. The interaction between pain, treatment and cognitive function is very complex and is far from understood. The hypothesis of the present study is that by use of experimental pain in healthy volunteers it will be possible to elucidate the interaction between pain, treatment and cognitive function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
DOUBLE
Enrollment
23
0.1microg/kg/min remifentanil administered as infusion Max infusion time is 20min
Mech-Sense, Department of Gastroenterology, Aalborg Hospital
Aalborg, Denmark
Cognitive function
Investigate the relationship between cognitive function and pain and treatment with remifentanil
Time frame: 3 experiments each lasting for about 4-6hours - total duration of study is around 8-9month
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