A Comparability Study of the Phase 3 Lot and a Single Commercial Lot of NicVAX in Healthy Adult Smokers

Inclusion Criteria: * Healthy male or female smokers, age 18-55, who are currently smoking at least 10 cigarettes per day. Exclusion Criteria: * Prior exposure to NicVAX or any other nicotine vaccine. * History of clinically significant allergic reactions. * Use of systemic steroids. * Cancer or cancer treatment within 5 years. * HIV infection. * History of drug or alcohol abuse or dependence. * Required treatment for depression within the past 12 months. * Body mass index ≥ 30 \[calculated as weight (kg)/height2 (m)\]. * Significant cardiovascular, hepatic, renal, psychiatric and/or respiratory disease. * Inability to fulfill all visits for approximately 30 weeks.