Influence Positive End-expiratory Pressure on Autoregulation in Patients With Respiratory Insufficiency

Johannes Gutenberg University Mainz20 enrolled

Overview

The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.

Cerebral blood flow velocity will be measured using transcranial Doppler sonography and then correlate with the invasive arterial blood pressure curve to calculate the index of cerebrovascular autoregulation Mx (Mx\>0.3 indicates impaired AR). The index of cerebrovascular autoregulation Mx was measured during baseline positive end-expiratory pressure (PEEP) levels and after lung recruitment with higher level of PEEP. The equality between this two PEEP levels was estimated and calculated with one side Wilcoxon test.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Respiratory Insufficiency

Interventions

positive end-expiratory pressurePROCEDURE

Elevation of positive end-expiratory failure for recruitment

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * respiratory failure * Age \>18 years * Invasive ventilation Exclusion Criteria: * Sepsis * preexisting cerebral illness * traumatic brain injury * meningitis or encephalitis * pregnancy

Locations (1)

University medical centre

Mainz, Germany

Outcomes

Primary Outcomes

Integrity of the cerebrovascular autoregulation (CA)

Cerebrovascular autoregulation will be calculated as a moving correlation index (Mx) from the cerebral blood flow velocity and the arterial blood pressure. It is a parameter without unit (index).

Time frame: 30 Minutes

Data from ClinicalTrials.gov

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