We propose to examine a population of Native Americans who have had little or no dental care, and to determine if periodontal disease is associated with early signs of vascular dysfunction or systemic inflammation. We then propose to treat the periodontitis and re-evaluate vascular function. We will determine if gingivitis or mild/moderate periodontitis is associated with detectable vascular dysfunction. Microbial metagenomics will be correlated with vascular function.
Study Type
OBSERVATIONAL
Enrollment
92
Indian Health Council
Valley Center, California, United States
Determination of bacterial populations in periodontal samples before and after standard periodontal treatment, stratified by severity of gum disease, using microbial metagenomics analysis.
The study will assess if periodontal bacterial flora differ in patients with healthy gums, mild, or severe periodontal disease.
Time frame: Time of enrollment and at 6 week follow up visit
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