Digital Ulceration

Inclusion Criteria: For all patients: * Signed informed consent prior to enrollment * Male or female, ≥ 18 years of age * Diagnosis of systemic sclerosis (SSc) according to the American College of Rheumatology and/or limited cutaneous SSc or diffuse cutaneous SSc according to LeRoy criteria For patients with no history of digital ulcers (DU) and no DU at enrollment only: \- Enrollment must be within 2 years of the first physician-documented non-Raynaud clinical feature Exclusion Criteria: * SSc sine scleroderma (without any skin involvement) * Patients who underwent stem cell transplantation * Participation in interventional clinical trials within 3 months prior to enrollment and/or during the study * Inability to undergo Nailfold Videocapillaroscopy (NVC) assessment (e.g., inability to extend fingers sufficiently)