Effects of Different Types of Exercise Interventions in Patients With Type 2 Diabetes

University of Giessen100 enrolled

Overview

The purposes of the study are * to determine which kind of supervised exercise intervention (aerobic endurance training versus strength endurance training versus combined aerobic endurance and strength endurance training) is more effective in improving the metabolic parameters in typ 2 diabetes patients * to investigate what kind of intervention is more successful in reduction of concomitant diseases and improving quality of life * to assess what kind of intervention induces highest effects in long term persistence of these positive changes

Meta-analyses which evaluated the effects of structured exercise programs in patients with type 2 diabetes demonstrate that regular physical activity improves glycosylated haemoglobin (König et al.: Resistance Exercise and Type 2 Diabetes Mellitus, Deutsche Zeitschrift für Sportmedizin Jahrgang 62, Nr. 1 (2011): 5-9). Sigal et al. proved that either aerobic or resistance training alone improved glycemic control in type 2 diabetes, but the improvements are greatest with combined aerobic and resistance training (Sigal, RJ, et al.: Effects of Aerobic Training, Resistance Training, or Both on Glycemic Control in Type 2 Diabetes, Ann Intern Med. 2007 Sep 18;147(6):357-69). Therefore, aim of the current study is to compare the effects of aerobic endurance training or resistance endurance training or the combination of aerobic endurance training and resistance endurance training in diabetes type 2 patients without any other lifestyle or dietary interventions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

100

Conditions

Type 2 Diabetes

Interventions

Aerobic endurance training interventionOTHER

The aerobic endurance training group will use cardiovascular training devices week 1-4: 15 minutes warm up (group) 15 minutes intervention at 80-100% vAT two times per week week 5-13: 15 minutes warm up (group) 30 minutes intervention at 95-110% vAT two times per week week 14-26: 15 minutes warm up (group) 45 minutes intervention at 95-110% vAT two times per week

Strength endurance training interventionOTHER

The strength endurance training intervention group will perform eight exercises on weight machines (Milon circuit training- 60 seconds activity, 30 seconds break) week 1-4: 15 minutes warm up (group) 1 session resistance training intensity 3 (Buskies) two times per week week 5-13: 15 minutes warm up (group) 2 sessions resistance training intensity 5 (Buskies) two times per week week 14-26: 15 minutes warm up (group) 3 sessions resistance training intensity 5 (Buskies) two times per week

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diagnoses of type 2 diabetes (ADA criteria) * admitted diabetes treatments will be diet and oral hypoglycemic agents Exclusion Criteria: * sports intervention \>60 minutes per week * medical conditions * preproliferative or proliferative retinopathy * instable coronary heart disease * inability to perform the scheduled physical activity programs * acute clinically significant intercurrent diseases

Locations (2)

University of Giessen

Giessen, Hesse, Germany

Sportpark Zwickau, Glauchau, Meerane

Zwickau, Saxony, Germany

Outcomes

Primary Outcomes

Change in HbA1c-level (haemoglobin A1c)

Time frame: 6 months

Secondary Outcomes

Change in HOMA-Index

Time frame: 3 and 6 months

Change in beta-cell-function

Measured by OGTT (Oral Glucose Tolerance Test)

Time frame: 3 and 6 months

Change in fasting plasma glucose levels

Time frame: 3 and 6 months

Change in total cholesterol levels

Time frame: 3 and 6 months

Change in HDL-cholesterol levels

Time frame: 3 and 6 months

Change in LDL-cholesterol levels

Time frame: 3 and 6 months

Change in triglyceride levels

Time frame: 3 and 6 months

Change in antidiabetic medications

Class and dosage of blood-glucose lowering drugs are recorded before, after 3 and 6 months

Time frame: 3 and 6 months

Change in inflammation markers

CrP, blood count, interleukinstatus, cytokinstatus

Time frame: 3 and 6 months

Change in body weight

Time frame: 3 and 6 months

Data from ClinicalTrials.gov

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