Preliminary retrospective data suggest that the relatively soluble but inexpensive volatile anesthesia isoflurane prolongs the duration of hospitalization compared to the less soluble but more expensive anesthetic sevoflurane. Even a small reduction in the duration of hospitalization would easily compensate for the modest additional cost of sevoflurane. The investigators therefore propose to test the primary hypothesis that duration of hospitalization is longer with isoflurane than sevoflurane. The investigators will also test the secondary hypotheses that: 1) pain scores are greater in patients recovering from isoflurane than sevoflurane anesthesia; and, 2) opioid consumption is greater after isoflurane than sevoflurane anesthesia. All statistical analyses will be adjusted for age, gender, race, baseline risk, 9 and procedure.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
1,584
Isoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist
Sevoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist
Cleveland Clinic
Cleveland, Ohio, United States
Hospital Length of Stay
Time frame: participants will be followed for the duration of hospital stay, an expected average of 3 days
Time-weighted Average Verbal Rating Pain Score
Time-weighted average VRS (Verbal Rating Scale) pain score over the first 72 h after surgery as recorded by nurses at approximately 4-h intervals. The VRS pain score is from 0 (no pain) to 10 (worst imaginable pain).
Time frame: up to 72 hours after surgery
Total Intraoperative Opioid Consumption
Total amount of opioid in IV morphine equivalents used during surgeyr
Time frame: intraoperative
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