Chronic Obstructive Pulmonary Disease (COPD)-patients (caused by smoking-level) and Alpha-1-Antitrypsin-deficiency patients showed different developments during rehabilitation in regard to improvement of 6-minute-walking distance. The aim of this study is to investigate differences between training adaptations in COPD-patients and Alpha-1-deficiency patients. Both groups take part in a standardized multimodal 3-week-rehabilitation with strength and endurance training. In addition to conventional diagnostic procedures, muscle biopsies from the M. vastus lateralis will be conducted before and after rehabilitation program followed by biochemical, histochemical and immunohistochemical analysis of the probes.
Study Type
INTERVENTIONAL
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
20
strength and endurance training, 5 time per week.
Klinikum Berchtesgadener Land
Berchtesgaden, Germany
aerobic and anaerobic enzymes
changes in quantity of enzymes from baseline to day 23
Time frame: day 2 and 23
maximal exercise capacity in incremental cycling test
Change in max. exercise capacity from baseline to day 23
Time frame: day 2 and 23
6-minute-walking distance
change in 6-minute-walking distance from baseline to day 24
Time frame: day 3 and 24
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