Argireline in Treatment of Periorbital Wrinkles

Mahidol University70 enrolled

Overview

The purpose of this study is to determine whether La Jolie gel is effective in the treatment of periorbital wrinkles.

Argireline has mechanism of action that significantly inhibited neurotransmitter release with a potency similar to that of BoNTA. Inhibition of neurotransmitter release was due to the interference of the hexapeptide with the formation and/or stability of SNARE complex. Notably, this peptide did not exhibit in vivo oral toxicity nor primary irritation at high doses. These findings demonstrate that Argireline is a anti-wrinkle peptide that emulates the action of currently used BoNTs. In vivo study, Topical Argireline 10% is applied on lateral preorbital area twice daily for 30 days. The result demonstrates a significant anti-wrinkle activity by decreased skin wrinkle 30%. These findings demonstrate a significant anti-wrinkle activity for Argireline, in agreement with its in vitro and cellular activities. Topical Argireline represents a bio-safe alternative to BoNTs in anti-wrinkle therapy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Wrinkles

Interventions

10% ArgirelineDRUG

10% Argireline (La jolie gel®, Pacific health care, Thailand) were instructed to apply the gel over the face and periorbital area twice daily for a period of 3 months.

Eligibility

Sex: FEMALEMin age: 35 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy woman at 35-45 years old * Presence of periorbital wrinkles Exclusion Criteria: * Pregnancy * Nursing * Keloids /scar at periorbital area * pre-treatment with topical periorbital products within 1 month * Botulinum toxin A injection,facial plastic surgery within 1 year * Allergic to active ingredients including acetyl hexapeptide-3 Argireline®, sodium hyaluronate,adenosine,arbutin,fucus vesiculosus)

Locations (1)

Department of dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkoknoi, Bangkok, Thailand

Outcomes

Primary Outcomes

Efficacy

Objective evaluation * Noninvasive measurement by skin bioengineering technique e.g. visioscan, corneometer, cutometer * Comparative photographic evaluation by certified dermatologists Subjective evaluation * Patient Self assessment satifaction review

Time frame: 3 months

Secondary Outcomes

Safety

Number of participants with adverse events Categorized adverse events

Time frame: 3 months

Data from ClinicalTrials.gov

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