Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy

Inclusion Criteria: Subjects Receiving Chemotherapy: * Have a diagnosis of invasive breast cancer (stage I-IIIC) or intermediate or high-grade\* lymphoma (\*defined by the treating physician) * Be scheduled to begin a course of chemotherapy * Oral chemotherapy is acceptable * Previous or concurrent treatment with hormones or biological response modifiers is acceptable. (Subjects receiving biological response modifiers only are not eligible). * Be chemotherapy naïve * Life expectancy greater than 10 months * Be able to speak and read English * Give written informed consent Inclusion Criteria, Controls: * Must be the same gender as the subject receiving chemotherapy * Must be within 5 years of the age of the subject receiving chemotherapy * Life expectancy greater than 10 months * Be able to speak and read English * Give written informed consent * Must be willing to participate in the study for the entire period Inclusion Criteria, Long-Term Followup Study: * Must be a subject who had breast cancer, or control who was paired with that subject with breast cancer, who provided CANTAB data at any time-point during assessments 1 through 3. Exclusion Criteria: Subjects Receiving Chemotherapy: * Must not be currently hospitalized or have been hospitalized within the last year for a psychiatric illness * Must not be diagnosed with a neurodegenerative disease * Must not have primary central nervous system (CNS) disease * Must not have received chemotherapy in the past * Must not be scheduled to receive concurrent radiation treatment * Must not have metastatic disease (subjects with breast cancer) * Must not be pregnant * Must not be colorblind Exclusion Criteria, Controls: * Must not be currently hospitalized or have been hospitalized within the last year for a psychiatric illness * Must not be diagnosed with a neurodegenerative disease * Must not have primary CNS disease * Must not have been diagnosed with cancer or previously have received chemotherapy * Must not be pregnant or plan on becoming pregnant during the study period * Must not be colorblind Exclusion Criteria, Long-Term Followup Study: * Must not have dementia or any severe neurodegenerative disease that would prohibit the ability to complete cognitive testing. * Must not be colorblind