Study To Investigate The Relative Bioavailability of OZ439 Formulations In Healthy Volunteers

Inclusion Criteria: * Healthy male and female volunteers between 18 and 55 years (inclusive). Post-menopausal women with amenorrhoea for at least 2 years are eligible confirmed by FSH level \>/ = 25microlU/ml * Body mass Index between 18 and 30 kg/m2, inclusive; and body weight \> 50 kg. * Healthy as determined by pre-study medical history, physical examination (including body temperature), 12 Lead ECG. * Male volunteers must agree to use a double barrier method of contraception including abstinence, condom plus diaphragm or condom plus IUD or condom plus stable oral/transdermal/injectable hormonal contraceptive by female partner for at least 14 days prior to the time of the first dose of study drug through 90 days after the last dose of study drug and must also agree to not donate sperm for 90 days after the last dose of study drug. Vasectomy with zero sperm count for 6 months minimum prior to the first dose of study drug is an acceptable form of contraception * Clinical laboratory tests at screening within the reference ranges or if outside the normal range not clinically significant. ALT, AST and total bilirubin must be within the normal range * Able and willing to give written informed consent * Willing and able to adhere to the lifestyle guideline requirements * Willing and able to be confined to the Clinical Research Unit as required by the protocol Exclusion Criteria: * Evidence of or history of clinically significant oncologic, pulmonary, hepatic, cardiovascular, hematologic, metabolic, neurological, immunologic, nephrologic, endocrine, psychiatric disease, or current infection * Evidence of or history of clinically significant gastrointestinal (excluding appendectomy and cholecystectomy) disease or current infection. * Any condition that could possibly affect drug absorption, e.g. gastrectomy, diarrhea * History of post-antibiotic colitis * Pregnancy or breastfeeding * QTc greater than 450 msec for males and females as corrected by the Fredricia's formula or evidence or history of abnormal cardiac rhythm * History of drug or alcohol abuse within the past 2 years prior to Screening * Tobacco users (includes stopping smoking less than 90 days prior to screening. "Tobacco use" includes smoking and the use of snuff and chewing tobacco, and other nicotine containing products * Received an investigational drug or participated in another research study within 30 days of the first dose of study drug in any part of the study * Use of prescription drugs within 14 days prior to the first dose of study drug in Period 1, or need for any antibiotic during the study * Received any non prescription medications, vitamins, herbal supplements or dietary supplements within 7 days of the first dose of study drug in Period 1, unless prior approval is granted. Excluded from this list is intermittent use of acetaminophen at doses of up to 2 g/day * Consumed alcohol within 72 hours of Day -1 in any part of the study, or have a positive alcohol screen at screening or each admission * Consumed fruit juice or ate grapefruit within 7 days prior to the first dose of study drug in any part of the study * Positive test for human immunodeficiency virus, hepatitis B surface antigen or anti-hepatitis C virus * Positive urine drug screen at Screening or admission * History of intolerance or hypersensitivity to artemisinins * Likelihood of requiring treatment during the study period with drugs not permitted by the study protocol * Volunteers who have donated blood or experienced significant blood loss within 90 days of screening * Hemoglobin \< 13.5 g/dL for males and \< 12.5 g/dL for females * Any concern by the investigator regarding the safe participation of the volunteer or any reason the investigator considers the volunteer inappropriate for participation