Cat allergy is an increasingly prevalent condition, affecting 10-15% of patients with allergic rhinoconjunctivitis. Cat-PAD is a novel, synthetic, allergen derived peptide desensitising vaccine currently being developed for treatment of cat allergy. At present, the efficacy of immunotherapy (peptide or otherwise) can only be established at the conclusion of therapy. No reliable predictive biomarkers of clinical efficacy currently exist. Identification of surrogate biomarkers of clinical efficacy, would facilitate clinical development of peptide immunotherapy vaccines, in addition to providing an improved understanding of the underlying molecular mechanisms of efficacy, thus providing new leads for therapeutic intervention.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
10
Intradermal injection 1 x 4 administrations 4 weeks apart
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada
Identification of a change in gene expression over the course of and potentially attributable to Cat-PAD treatment.
Time frame: 6 months following treatment
Symptom scores for ocular and nasal symptoms
Time frame: 4 weeks following treatment
Interleukin production and eosinophil level changes
Time frame: 4 weeks following treatment
Functional genomic changes
Time frame: 4 weeks following treatment
Changes in urine metabolomic profiles
Time frame: 4 weeks following treatment
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