Effect Of Piperine In Patients With Oropharyngeal Dysphagia

Hospital de Mataró40 enrolled

Overview

Piperine acts on the oropharyngeal TRPV1, increasing sensory input and the release of substance P. These actions may accelerate the oropharyngeal swallow response, improving the swallowing of dysphagic patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Deglutition Disorders

Interventions

PiperineDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age\>18 * History of swallowing difficulties associated with aging and/or neurological diseases (neurodegenerative or non-progressive neurological diseases) * Study explained and written subject information given * Informed consent signed Exclusion Criteria: * Patients suffering idiosyncratic phenomena or who are allergic to any medication, especially iodinated contrast media * Patients suffering major respiratory disease or undergoing any type of surgery in the three months prior to the study * Patients with a background of alcohol dependence or other drug dependence * Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of the study

Locations (1)

Hospital de Mataró

Mataró, Barcelona, Spain

Outcomes

Primary Outcomes

Safety of swallow

Prevalence of penetrations at the laryngeal vestibule

Time frame: 15 minutes

Secondary Outcomes

Efficacy of swallow

Prevalence of oral and pharyngeal residue

Time frame: 15 minutes

Data from ClinicalTrials.gov

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