Clinical Risk State for Bipolar Disorder in Adolescents

Northwell Health402 enrolled

Overview

Aim: The purpose of the study is to characterize the at-risk phases preceding a first episode of bipolar disorder and of schizophrenia, and to identify clinical and biological predictors of the disease development. Hypothesis a: Over 6-24 months, 25% of at-risk youth will develop the full manifestations of Bipolar Disorder (BPD) or schizophrenia. Hypothesis b: The symptoms utilized for characterizing the at-risk phase of BPD will differentiate between individuals developing BPD and schizophrenia.

Prospective, naturalistic, cohort study aiming to characterizing the bipolar and psychotic prodrome thoroughly with a variety of clinical and biological measures.

Study Type

OBSERVATIONAL

Enrollment

402

Conditions

Bipolar Disorder Schizophrenia

Eligibility

Sex: ALLMin age: 12 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age: 12-18 years; 2. Sex: male or female; 3. Race/ethnicity: no restrictions; 4. Definite or suspected chart diagnosis of BP-II, BP-NOS, cyclothymia, MDD, depressive disorder NOS, dysthymia or mood disorder NOS, schizophrenifiorm disorder or psychotic disorder NOS; 5. Subject and parent (if subject\<18) willing and able to provide written, informed consent/assent. Exclusion Criteria: 1. Estimated Premorbid IQ \< 70; 2. Meets DSM-IV criteria for BP-I or schizophrenia, pervasive developmental disorder, autism spectrum disorders, current substance dependence; 3. History of medical condition known to affect the brain; 4. current group home affiliation.

Locations (1)

The Zucker Hillside Hospital, NSLIJ

Glen Oaks, New York, United States

Outcomes

Primary Outcomes

Number of subjects with development of a bipolar or schizophrenia disorder

Diagnostic conversion

Time frame: within 60 months

Secondary Outcomes

Psychopathology

Time frame: within 60 months

Data from ClinicalTrials.gov

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