Confocal Endomicroscopy Detection of Gastric Preneoplasia and Neoplasia

Inclusion Criteria: 1. The subject is Chinese 2. The subject is greater than 50 years of age 3. The subject satisfies one or more of the following criteria: * has (had) a history of dyspepsia of at least 4 weeks or more. Dyspeptic symptoms include bloating, epigastric discomfort and early satiety * has a family history of gastric cancer * has a medical condition for which an OGD is indicated. 4. The subject must have personally signed and dated the patient informed consent form indicating that he/she has been informed of all pertinent aspects of the study. 5. The subject must be willing and able to comply with scheduled visits and other study procedures Exclusion Criteria: 1. The subject who has bleeding disorders, such as haemophilia, in whom biopsies are contraindicated. 2. The subject with liver cirrhosis. 3. The subject with previous total or partial gastrectomy. 4. The subject with severe co-morbid illness, such as end-stage renal failure (ESRF), congestive cardiac failure (CCF), severe osteoarthritis (OA) and rheumatoid arthritis (RA) requiring long term non-steroidal anti-inflammatory drug (NSAID) therapy. 5. The subject has other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may interfere with the interpretation of study results and in the judgment of the investigator would make the subject unsuitable for entry into the study. 6. The subject is currently on anti-coagulant therapy such as warfarin. Patients on aspirin, ticlopidine and clopidogrel must undergo a one-week washout period before enroling in the study. 7. The subject has a history of bronchial asthma, or a known allergy to fluorescein. 8. The subject is unwilling or unable to provide signed informed consent.