Effect of Glucose-insulin-potassium Solution on Myocardial Protection During Off-pump Coronary Bypass Surgery in Patients With Acute Coronary Syndrome

Yonsei University66 enrolled

Overview

Patients undergoing multivessel off-pump coronary bypass surgery (OPCAB) inevitably experience cumulative ischemia-reperfusion injury at myocardium. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion on myocardium in patients undergoing OPCAB. Patients undergoing OPCAB with acute coronary syndrome are randomly assigned to GIK or Control group. The trial is double-blind and conducted at a single center.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Acute Coronary Syndrome

Interventions

GIK solution

Patients receive 0.3 ml/kg/hr GIK solution or the same volume of normal saline depending on the group during off-pump coronary bypass surgery. GIK solution consist of 50% glucose, potassium 80 mEq, and regular insulin 325 IU/500ml.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing isolated OPCAB. * Age: 20\~75. Exclusion Criteria: * Emergency operation. * Patients with MR ≥ 2. * Patients with IDDM. * Patients with random sugar ≥ 250 mg/dL. * Patients with serum creatinine ≥ 2.0 mg/dL. * Patients with acute myocardial infarction within 1 week of surgery

Locations (1)

Severance Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

CK-MB(creatinine kinase-MB) mass

Comparison of cardiac enzyme elevation after surgery between GIK and Control group.

Time frame: 12 hours after the surgery

Data from ClinicalTrials.gov

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