The hypothesis of this study is that Prostaglandin E2 (PGE2) induces headache and dilatation of brain vessels in migraine patients without aura.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
QUADRUPLE
Enrollment
12
intravenous injection 0.4 μgr/kg/min for 25 min
intravenous injection for 25 min
Danish Headache Center
Glostrup Municipality, Denmark
Headache score on a 10-point verbal rating scale (VRS).
Incidence of headache 0 indicated no headache; 1 indicated a different sensation, pounding or throbbing, but not necessarily painful; 5 indicated moderate headache and 10 indicated worst imaginable headache.
Time frame: 24 h
Blood flow velocity in the middle cerebral artery (VMCA) measured by a Transcranial Doppler (TCD) ultrasonography (2MHz).
Changes from base line recorded every 10th min. until time 90 min on day 1 and day 2. The infusion takes 25 min from time 0.
Time frame: 90 min
Diameter of superficial temporal artery and radial artery measured by a high resolution ultrasound scanner, C-scan.
Changes from base line recorded every 10th min. until time 90 min on day 1 and day 2. The infusion takes 25 min from time 0.
Time frame: 90 min
Mean arterial blood pressure (MAP).
Changes from base line recorded every 10th min. until time 90 min on day 1 and day 2. The infusion takes 25 min from time 0.
Time frame: 90 min
Electrocardiography (ECG).
Changes from base line recorded every 10th min. until time 90 min on day 1 and day 2. The infusion takes 25 min from time 0.
Time frame: 90 min
Heart rate (HR).
Changes from base line recorded every 10th min. until time 90 min on day 1 and day 2. The infusion takes 25 min from time 0.
Time frame: 90 min
End-tidal partial pressure of pCO2 (PetCO2).
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Changes from base line recorded every 10th min. until time 90 min on day 1 and day 2. The infusion takes 25 min from time 0.
Time frame: 90 min
Transcutaneous arterial oxygen saturation (SAT)
Changes from base line recorded every 10th min. until time 90 min on day 1 and day 2. The infusion takes 25 min from time 0.
Time frame: 90 min