Effects of Non-invasive Ventilation on Rehabilitation Outcome in COPD-patients

Schön Klinik Berchtesgadener Land31 enrolled

Overview

The aim of the study is to find out if nocturnal non-invasive ventilation during pulmonary rehabilitation increases exercise capacity and quality of life more than pulmonary rehabilitation alone.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

pulmonary rehabilitationPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * confirmed diagnosis of COPD in stages GOLD III/ IV * receiving optimized medical treatment and long term oxygen therapy if needed * patients consent to participate in this trial * no treatment with NIV in the last 4 weeks * treatment with NIV in the last 4 weeks due to an acute exacerbation Exclusion Criteria: * treatment with NIV in the last 4 weeks (except due to an acute exacerbation) * Intolerance to perform NIV * Acute exacerbation at baseline or during PR * Hypercapnia \> pCO2 55mmHg * Inability to perform a 6 minute walking test

Locations (1)

Schön Klinik Berchtesgadener Land

Schönau am Königssee, Germany

Outcomes

Primary Outcomes

change in 6 minute walking distance

change in 6 minute walking distance from baseline to day 25

Time frame: day 1 and 25

Secondary Outcomes

change in quality of life (chronic respiratory questionnaire, CRQ)

change in CRQ-Score from baseline to day 25

Time frame: day 1 and 25

change quality of life (Saint George´s Respiratory Questionnaire, SGRQ)

change in SGRQ-Score from baseline to day 25

Time frame: day 1 and 25

Data from ClinicalTrials.gov

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