Zotarolimus-eluting Endeavor Sprint Stent in Uncertain DES Candidates (ZEUS) Study

Inclusion Criteria: A) low restenosis risk based on angiographic findings defined as follows: ----patients will be considered at low restenosis risk if no planned stent lower than 3.0 mm is intended to be implanted in lesions expect left main or vein graft B) high bleeding risk and/or presence of relative-absolute contraindication to dual anti-platelet treatment beyond 30 days defined as follows: 1. Clinical indication to treatment with oral anticoagulant, including use of warfarin or dabigatran or other oral anticoagulant agents 2. Recent (within previous 12 months) bleeding episode(s) which required medical attention 3. Previous bleeding episode(s) which required hospitalization if the bleeding diathesis has not been completely resolved (i.e. surgical removal of the bleeding source) 4. Age greater than 80 5. Systemic conditions associated to increased bleeding risk (e.g. hematological disorders or any known coagulopathy determining bleeding diathesis, including history of or current thrombocytopenia defined as platelet count \<100,000/mm3 (\<100 x 109/L). 6. Known Anemia defined as repeatedly documented hemoglobin lower than 10 gr/dl which is not due to an acute and documented blood loss 7. Need for chronic treatment with steroids or NSAID C) Patients at high thrombosis risk based on the presence of at least one of the following criteria: 1. Allergy/intolerance to aspirin 2. Allergy/intolerance to clopidogrel AND ticlopidine 3. Planned surgery (other than skin) within 12 months of percutaneous coronary intervention (PCI). 4. patient with cancers (other than skin) and life expectancy \>1 year 5. Patients with systemic conditions associated with thrombosis diathesis (e.g., hematologic disorders and any known systemic conditions determining a pro-thrombotic state including immunological disorders) \- Exclusion Criteria: * Any of the following: 1. Women who are pregnant. Women of childbearing potential must have a negative pregnancy test (urine or serum HCG) within 7 days prior to randomization; as close to randomization as possible, within 24 hours preferred. 2. Subjects who are unable to give informed consent and assurance for complete contact through 12 months. 3. PCI with stenting in the previous 6 months