The purpose of this study is to evaluate the effect of mulberry leaf extract on blood glucose in subjects with impaired fasting glucose.
The purpose of this study is to evaluate the effect of mulberry leaf extract on blood glucose in subjects with impaired fasting glucose. After 2 weeks run-in period for wash-out, subjects will randomly assigned to two groups, i.e. control group (placebo) or mulberry leaf extract group. They will intake placebo or mulberry leaf extract for 4 weeks. Biomarkers will be analyzed in blood samples in 0 and 4 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
40
18 tablets/day (6 tablets/serving x 3servings/day, mulberry leaf extract 336mg/1 tablet (800mg), 1-Deoxynojirimycin 4.3mg/1 g mulberry leaf extract), Duration: 4 weeks
18 tablets/day (6 tablets/serving x 3servings/day, lactose 511mg/1 tablet (650mg)), Duration: 4 weeks
Bundang CHA Medical Center
Seongnam-si, Gyeonggi-do, South Korea
Blood glucose change with meal tolerance test
Time frame: 0wk
Blood glucose change with meal tolerance test
Time frame: 4wk
Insulin and C-peptide changes with meal tolerance test
Time frame: 0, 4 wk
Fasting blood glucose
Time frame: 0, 4 wk
Insulin
Time frame: 0, 4wk
C-peptide
Time frame: 0, 4wk
Glycated albumin
Time frame: 0, 4wk
High sensitivity C-reactive protein
Time frame: 0, 4wk
Oxidized low-density lipoprotein
Time frame: 0, 4wk
Malondialdehyde
Time frame: 0, 4wk
Lipid profile (triglyceride, total cholesterol, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, high-density lipoprotein cholesterol)
Time frame: 0, 4wk
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