A PK-PD Study of PSN821 in Type 2 Diabetes Patients (T2DM)

Inclusion Criteria: * Patients with Type 2 diabetes according to the American Diabetes Association criteria, diagnosed at least 12 months prior to screening. * Male or female, between 18 and 75 years of age, inclusive. * Body Mass Index of 25 - 45 kg/m2, inclusive. * Diabetes managed on a stable regimen of diet, exercise and metformin monotherapy (without dosage adjustments within 4 weeks prior to screening). * Haemoglobin A1c (HbA1c) of 7.5 10% at screening. * Fasting plasma glucose (FPG) of between 7 - 13.3 mmol/L at screening and Day -1. * Males who are, and whose partners are able to comply with contraceptive advice. * Females of non child-bearing potential. * Willing to sign the written Informed Consent Form (ICF) to participate in the study and to abide by the study restrictions. Exclusion Criteria: * Patients with Type 1 diabetes or maturity onset diabetes of the young or secondary forms of diabetes, such as due to pancreatitis. * Marked diabetic complications. * Illness or medication that impacts on the scientific integrity of the study.