A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery

Baskent University40 enrolled

Overview

The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents regarding their effect on adrenal gland steroid synthesis in these patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Coronary Artery Bypass Surgery

Interventions

KetamineDRUG

During standard anesthesia induction with fentanyl and midazolam, ketamine 2 mg/kg IV will be administered

EtomidateDRUG

During standard anesthesia induction with fentanyl and midazolam, etomidate 3 mg/kg IV will be administered

Eligibility

Sex: ALLMin age: 30 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients scheduled for elective coronary artery bypass graft surgery with cardiopulmonary bypass * Patient's written informed consent for study participation * Ejection fraction ≥ 35% Exclusion Criteria: * Allergy to study drugs * Redo surgery

Locations (1)

Baskent University, Faculty of Medicine

Ankara, Çankaya, Turkey (Türkiye)

RECRUITING

Outcomes

Primary Outcomes

A more than 15% change in mean arterial pressure and heart rate after anesthesia induction

Time frame: For 60 minutes after anesthesia induction

Secondary Outcomes

Adrenal gland steroid synthesis suppression

A less than 9 microgram/dl increase in serum cortisol after stimulation with adrenocorticotropic hormone

Time frame: 24 hours and 5 days after study drug administration

Central Contacts

Özgür Kömürcü

CONTACT

+90 312 215 99 41 zgrkom@gmail.com

Arash Pirat

CONTACT

+90 312 212 68 68 araspirat@gmail.com

Data from ClinicalTrials.gov

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