To describe how Nulojix (belatacept) is used and to determine how often Post-Transplant Lymphoproliferative Disorder (PTLD), Central Nervous System (CNS) PTLD and Progressive Multifocal Leukoencephalopathy (PML), rare and serious complications of transplant treatment, occur in patients taking Nulojix (belatacept) in a real-world setting.
Time Perspective: Prospective for the majority of patients who are enrolled at the time they begin Nulojix (belatacept) treatment. Retrospective for any patients receiving Nulojix (belatacept) prior to enrollment into ENLiST Registry
Study Type
OBSERVATIONAL
Enrollment
914
No Intervention. Subjects are previously treated with Nulojix (belatacept)
Incidence rate of confirmed PTLD in US adult de novo Epstein Barr Virus (EBV)-seropositive kidney transplant recipients treated with Nulojix (belatacept) in clinical practice
Time frame: Every 6 months for up to 72 months
Incidence rate of confirmed CNS PTLD in US adult de novo Epstein Barr Virus (EBV)-seropositive kidney transplant recipients treated with Nulojix (belatacept) in clinical practice
Time frame: Every 6 months for up to 72 months
Incidence rate of PML in confirmed PML in US adult de novo Epstein Barr Virus (EBV)-seropositive kidney transplant recipients treated with Nulojix (belatacept) in clinical practice
Time frame: Every 6 months for up to 72 months
Demographic, clinical and treatment characteristics of patients receiving Nulojix (belatacept)
Time frame: Every 6 months for up to 72 months
Rates of graft survival observed in the Nulojix (belatacept) treated patients
Time frame: Every 6 months for up to 72 months
Rates of patient survival observed in the Nulojix (belatacept) treated patients
Time frame: Every 6 months for up to 72 months
Incidence rate of confirmed PTLD and confirmed CNS PTLD by baseline CMV serostatus among Nulojix (belatacept) treated population
Time frame: Every 6 months for up to 72 months
Incidence rates of total reported PTLD, reported CNS PTLD and reported PML in adult de novo EBV seropositive kidney transplant recipients treated with Nulojix (belatacept)
Time frame: Every 6 months for up to 72 months
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University of Arizona
Tucson, Arizona, United States
University of California, Los Angeles
Los Angeles, California, United States
USC University Hospital
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San Francisco, California, United States
University of Colorado School of Medicine
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Denver Nephrologists
Denver, Colorado, United States
Yale University (Yale New Haven Hospital)
New Haven, Connecticut, United States
...and 26 more locations
Incidence rates of total reported PTLD and of total reported CNS PTLD by baseline CMV serostatus among Nulojix (belatacept) treated patients
Time frame: Every 6 months for up to 72 months