Multiple Ascending Dose Trial of BYK324677 in Healthy Volunteers

Inclusion Criteria: * Given written informed consent * Healthy male and female subjects. Assessed as healthy based on a screening examination including medical history, physical examination, blood pressure (systolic ≤140 mmHg, diastolic ≤90 mmHg), pulse rate (within 45-95 bpm), ECG assessment, and clinical laboratory results * Body mass index (BMI) between ≥18 and ≤28 kg/m², and a body weight ≥60 kg Exclusion Criteria: * History or current evidence of specified diseases * History of malignancy in the past 5 years * Gain or loss in body weight of more than 5% within the last 2 months or use of weight-loss medication within the last 3 months * ECG abnormalities of clinical relevance * Suspected hypersensitivity to the trial medication * Positive virology tests indicating acute or chronic infections * Clinically relevant laboratory parameters outside a specified range * Use of specified medications within certain time frames or use of certain co-medications * Abuse of alcohol or drugs * Dietary habits that would prevent from taking standardised meals * Female subjects: positive pregnancy test; lack of medically reliable methods of contraception during the trial * Donation of blood * Smoking within the last 3 months