Beta 1 Adrenergic antagonists (beta blockers) have major role in the treatment of CHF, IHD and hypertension. However, there is large interindividual variability in the response to beta blockers. The hypothesis underlying this study is that genetic differences between individuals will determine the individual response to esmolol, a betablocker that is administered intravenously. Esmolol will be administered intravenously to healthy volunteers, and the effects on heart rate and blood pressure will be monitored. In addition, we will measure plasma renin activity and plasma levels of norepinephrine.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
100
consecutive infusions of esmolol and normal saline (placebo)
Hadassah Hebrew University Medical Center
Jerusalem, Israel
RECRUITINGChange in heart rate during exercise
continous measurement of heart rate
Time frame: 3 hours
change in systolic blood pressure during exercise
measurement of systolic blood pressure every 5 minutes
Time frame: 3 hours
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