Ischemic stroke (IS) causes high mortality and severe disability. To improve outcome it's very important to choose the right way of the management of the patient and an appropriate drugs. There is a large number of the so-called neuroprotective drugs, which were effective in laboratory, but didn't show positive results in clinical studies with using traditional clinical scales scores as a primary outcome measures. Specialists suggest, that the investigators could receive better results if the investigators change design of the studies, particularly if the investigators select more precise and sensitive method of assessment. Aim of this study: to determine the role of navigated brain stimulation (NBS) for evaluation of the changes in the motor centers and motor tracts after administration of different cerebroprotective drugs. (The substances won't be compared to each other).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
30
citicoline IV 2000 mg, then citicoline 900 mg/day (300mg\*3 times per day) per os
choline alfoscerate IV 1000mg daily 10 days
Cerebrolysin IV 10 ml daily 10 days
Clinical Institute of Brain
Yekaterinburg, Sverdlovsk Oblast, Russia
MEP(motor evoked potential) parameter: motor threshold
Time frame: 2 months
MEP(motor evoked potential) parameter: latency
Time frame: 2 months
MEP(motor evoked potential) parameter: amplitude
Time frame: 2 months
Medical Research Council (MRC) Scale for Muscle Strength scores
Time frame: 2 months
Barthel index
Time frame: 2 months
Modified Rankin Scale (mRS)
Time frame: 2 months
Number of Participants with Adverse Events
Time frame: 2 months
Change from Baseline in Alpha waves percentage
EEG parameter
Time frame: 2 months
Change from Baseline in Beta waves percentage
EEG parameters
Time frame: 2 months
Change from Baseline in Delta waves percentage
EEG parameter
Time frame: 2 months
Change from Baseline in Theta waves percentage
EEG parameter
Time frame: 2 months
Presence of the abnormal epileptiform activity
EEG parameters
Time frame: 2 months
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