Inhaled Iloprost in the Treatment of Patients With Pulmonary Hypertension up to 4 Years

Inclusion Criteria: * Patients who has pulmonary hypertension treated with inhaled iloprost older than 18 years old. * Primary (idiopathic and familial) pulmonary hypertension (PH) with New York Heart Association (NYHA) functional class and exercise capacity, defined as class III and IV. * Pulmonary arterial hypertension (PAH) due to scleroderma with New York Heart Association (NYHA) functional class and exercise capacity, defined as class III and IV. * Patients who signed written informed consent. Exclusion Criteria: * Severe coronary heart disease or unstable angina; Myocardial infarction within the last six months; Decompensated cardiac failure if not under close medical supervision; * Severe arrhythmias; * Cerebrovascular events (e.g. transient ischaemic attack, stroke) within the last 3 months. * Pulmonary hypertension due to venous occlusive disease. * Congenital or acquired valvular defects with clinically relevant myocardial function disorders not related to pulmonary hypertension. * Pregnancy and lactation * Age below 18