Pharmacokinetics, Pharmacodynamics and Safety Evaluation of SAR279356 in Intensive Care Unit Mechanically Ventilated Patients

Inclusion criteria : * ICU patients on mechanical ventilation at the time of randomization * Patients or legally authorized representative (LAR) giving written informed consent. Exclusion criteria: * Patients \<18 years of age; * Documented Pseudomonas infection or colonization in the last 30 days; * Immunocompromised patients * Hypersensitivity to the study drug and/or to prior therapy with monoclonal antibodies; * Patient who has taken other investigational drugs or prohibited therapy for this study within 1 month or 5 half-lives, whichever is longer; * Patient or LAR who withdraws consent during the screening (starting from signed informed consent form); * Acute liver injury related criteria at the time of study entry: * Pregnant or breast-feeding women The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.