Remote Ischemic Preconditioning in Aortic Valve Surgery

University Hospital, Angers100 enrolled

Overview

RIP-VALVE is a randomized, single blinded study that will test the hypothesis that remote ischemic preconditioning initiated before surgery reduces post-operative myocardial damage in aortic valve surgery. Infarct size will be determined by 72 hours area under curve of troponin-I.

The hypothesis tested in this research proposal is that remote ischemic preconditioning initiated immediately before aortic valve surgery reduces myocardial damage related to surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

100

Conditions

Aortic Valve Stenosis

Interventions

ControlPROCEDURE

Deflated blood pressure cuff placed on upper arm for 30min

Remote ischemic preconditioningPROCEDURE

Blood pressure cuff placed on upper arm and inflated to 200 mmHg for 5 min and then deflated for 5 min. This cycle is initiated before aortic clamping and repeated 3 times in total

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 * Aortic valve surgery for aortic stenosis * Written informed consent Exclusion Criteria: * Aortic valve surgery combined with CABG or an other valve surgery * Previous Q-wave myocardial infarction or previous coronary artery bypass graft * Coronary artery stenosis \>70% * Ejection fraction \<35% * Surgery performed in emergency * Nicorandil ou metformin treatment within 8 days before surgery * Patient refusal / patient not having provided written informed consent.

Locations (1)

University Hospital, Angers

Angers, France

Outcomes

Primary Outcomes

Infarct size

Infarct size as assessed by 72 hours area under curve serum troponin-I

Time frame: 72 hours

Data from ClinicalTrials.gov

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