Rest/Stress Quantification Of Left Ventricular Dyssynchrony By 3D Gated Blood Pool D-SPECT

University Hospital, Clermont-Ferrand30 enrolled

Overview

Cardiac Resynchronization Therapy (CRT) is an established treatment for patients with advanced heart failure and left ventricular dyssynchrony (LVD). Too many patients do not clinically improve with CRT. New LVD markers other than QRS duration are needed. Study objective : feasibility assessment of rest and real-time stress 3D Blood-Pool Gated SPECT (BPGS) with a new designed cardiac imaging camera (DSPECT, Spectrum Dynamics®, Ceasaria, Israel) to quantify LVD.

Sequential 5 min Gated blood pool D-SPECT acquisition at rest and during last stage of dobutamine and atropin infusion (\>85% PHR). Rest and stress left ventricular ejection fraction, phase standard deviation and entropy will be determined using a fully automatic commercial software (QBS, Cedars-Sinai, Los Angeles, CA).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Left Ventricular Dyssynchrony

Interventions

3D Blood-Pool Gated SPECT (BPGS) with a new designed cardiac imaging camera (DSPECT, Spectrum Dynamics®, Ceasaria, Israel)DEVICE

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: Chronic heart failure with LVEF \< 35 %, QRS \> 120 ms, NYHA III/IV, optimal medical therapy for more than one month. * Patient with stable hemodynamic for more than one month, * More than 18-year old man or woman, * Patient having given his free, inform and signed consent, * Patient place setting by the social security system, Exclusion Criteria: * Psychiatric disorder * Any contra-indication to Technetium, * Any contra-indication to dobutamin or atropin * Personal or family history of sudden death * Previous severe ventricular arrhythmia * Obstructive cardiomyopathy, severe aortic stenosis, * Pulmonary hypertension, * History of renal, lung, hepatic, cardiac transplantation, * Pregnant or breast-feeding Woman, * Patient who can not conform to the requirements of the protocol, * Patient included in another medical study,

Locations (1)

CHU de CLERMONT-FERRAND

Clermont-Ferrand, France

RECRUITING

Outcomes

Primary Outcomes

Left ventricular phase standard deviation.

Secondary Outcomes

Left ventricular entropy

Left ventricle ejection fraction

Quality of life.

6-minutes walking test

Central Contacts

Patrick LACARIN

CONTACT

04 73 75 11 95 placarin@chu-clermontferrand.fr

Data from ClinicalTrials.gov

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