Surveillance and Proactive Intervention for Dialysis Access

N/AWithdrawnNCT01391975

University of Hull

Overview

Newly formed dialysis fistulae can often fail, and failure is usually due to narrowing of the blood vessels. Methods of detecting narrowing are available and, more importantly, can detect narrowings before a fistula fails. It is not known whether treating these narrowings will actually improve fistula survival or if the majority can be left alone. we wish to see if we can detect such narrowings with ultrasound scanning and if early detection and treatment improves patient outcomes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Conditions

Renal Failure Arteriovenous Fistula

Interventions

Active ultrasound surveillance of fistula and proactive treatment of stenosisPROCEDURE

Regular duplex ultrasound assessment of fistula from time of creation until 6 months post procedure with referral of all haemodynamically significant stenoses to further imaging and treatment

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Incident patients referred to vascular or transplant surgery departments for primary AV fistula formation for haemodialysis access. 2. Ability to give informed written consent 3. Aged over 18 at time of referral Exclusion Criteria: 1. Inability to give informed written consent 2. Aged under 18 at time of referral 3. Inability to attend follow-up appointments Specific exclusion; 1. Previous arteriovenous access procedures in target limb 2. Unsuitable for upper limb radiocephalic or brachiocephalic AVF formation 3. Known thrombophilic or thrombotic pathology

Locations (1)

Hull Royal Infirmary

Hull, United Kingdom

Outcomes

Primary Outcomes

Cumulative or secondary patency

This being the interval from the time of access placement until access abandonment, thrombosis, or the time of patency measurement including intervening manipulations (surgical or endovascular interventions) designed to re-establish functionality in thrombosed access.