Direct non-invasive coronary imaging by computed tomography (CT) has the potential to improve the workup of patients with stable chest pain complaints. The objective of the study is to compare in a randomized fashion the effectiveness and efficiency of a CT angiographic driven workup of suspected coronary artery disease in comparison to the standard workup using stress testing.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
350
Cardiac CT: calcium scan and CT coronary angiography
Standard care according to international guidelines
MC Haaglanden
Leidschendam, Netherlands
Erasmus MC
Rotterdam, Netherlands
Havenziekenhuis
Rotterdam, Netherlands
Maasstadziekenhuis
Rotterdam, Netherlands
Chest pain
Reduction of chest pain symptoms by standardized questionnaire, at one year follow-up
Time frame: 1 year
Class IA Revascularizations
Number of revascularizations with an ESC class 1A indication
Time frame: 1 year
Overall medical expenses
Overall medical expenses
Time frame: 1 year
Cost-effectiveness
Cost-effectiveness analysis based on the overall quality of life and medical expenses at one year.
Time frame: 1 year
Radiation dose
Cumulative radiation exposure at one year
Time frame: 1 year
Major adverse cardiovascular events
Composite endpoint of adverse cardiovascular events, including: All-cause mortality Non-fatal myocardial infarction Unstable angina requiring hospital admission Late revascularization procedures (\>6 months after initial evaluation)
Time frame: 1 year
Quality of life
Change of quality of life at 1 year
Time frame: 1 year
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