Cognitive Remediation for Cocaine Dependence

The University of Texas Health Science Center, Houston119 enrolled

Overview

The purpose of this study is to evaluate treatments designed to improve cocaine treatment success by combining medications that target cocaine-related cognitive impairments.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

119

Conditions

Cocaine Dependence

Interventions

levodopa/carbidopaDRUG

800/200 mg/d

Ropinirole 2 mg/dDRUG

2 mg/d

PlaceboDRUG

sugar pill

Ropinirole 4 mg/d

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * meet criteria for cocaine dependence * seeking treatment for cocaine dependence * be in acceptable health based on medical history and physical exam Exclusion Criteria: * dependent on drugs other than cocaine, nicotine, marijuana * have a medical condition contraindicating treatment with study medications * having conditions of probation or parole requiring reports of drug use to officers of the court

Locations (1)

Behavioral and Biomedical Sciences Building

Houston, Texas, United States

Outcomes

Primary Outcomes

Cocaine Use Based on Urine Drug Screening

The mean of the predicted probabilities (derived from generalized linear mixed models) of negative drug screens over all 10 weeks is reported, as per the analysis proposed in the protocol.

Time frame: 10 weeks

Secondary Outcomes

Number of Participants Who Completed the 10 Week Trial

Time frame: 10 weeks

Data from ClinicalTrials.gov

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