Delayed Umbilical Cord Clamping Versus Cord Milking in Preterm Neonate

Medstar Health Research Institute2 enrolled

Overview

This study is being done to evaluate if delaying cord clamping or milking the umbilical cord of the preterm infant has health benefits for the baby. Timing of clamping of the cord varies among doctors, but there is information that shows that delaying clamping of the umbilical cord in premature infants may reduce the rate of the baby needing a blood transfusion, decrease the risk of infection and bleeding in the head.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Premature Birth

Interventions

Delayed cord clampingPROCEDURE

Delay cord clamping for 30 seconds after birth

Milking of the cordPROCEDURE

Milking of the cord 4 times in 10 seconds

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Singleton or multiples pregnancies in patients admitted for medically indicated delivery or in advanced spontaneous preterm labor with imminent delivery at 24 0/7 - 28 6/7 weeks gestation * Women ages 18 and older Exclusion Criteria: * Planned vaginal breech delivery * Major fetal abnormalities (defined as those that are lethal or require prenatal or postnatal surgery) * Fetal death in utero * Red cell isoimmunization * Patients who are incapable of informed consent (unconscious, severely ill, mentally handicapped), or are unwilling to undergo randomization * Placenta previa or other known abnormal placentation (e.g. placenta accreta)

Outcomes

Primary Outcomes

Adverse Neonatal Event

composite of bronchopulmonary dysplasia (BPD), necrotising eneterocolitis (NEC), grade 3 or 4 intraventricular hemorrhage (IVH) or periventricular leukomalacia (PVL), or death prior to discharge home