Study participants received dronabinol (0, 120mg/day and 240mg/day) for 12 consecutive days in a randomized order. During each dronabinol maintenance period they were able to self-administer active or placebo cannabis using either a progressive ratio schedule or choice between cannabis and monetary alternative.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
25
Participants receive 40mg dronabinol 3 times daily
Participants receive placebo
Participants receive 80mg dronabinol 3 times daily
Johns Hopkins University (Bayview Campus)
Baltimore, Maryland, United States
Marijuana Self-administration - Progressive Ratio
Participants will be able to self-administer cannabis cigarettes (weighing about 0.8 grams and with about 6% THC) under a progressive ratio schedule. The number of progressive ratios completed (and thus, cannabis cigarettes consumed) is the primary study endpoint
Time frame: 12-day Dronabinol maintenance period
Marijuana Self-administration - Drug Vs Money Choice
Participants will be able to self-administer cannabis cigarettes (weighing about 0.8 grams and with about 6% THC) in 5 discrete choices each day between one cannabis cigarette and $1. The number of cannabis cigarettes chosen (and subsequently self-administered) is the primary study endpoint
Time frame: 12-day Dronabinol maintenance period
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