Influence of Respiratory and Exercise Therapy on Oxygen Uptake, Quality of Life and Right Ventricular Function in Severe Pulmonary Hypertension

Inclusion Criteria: * Consent form * men and women\> 18 years \<75 years * invasively confirmed chronic PH who have received complete diagnostic evaluation by specialized doctors / physicians according to the WHO classification at a center for pulmonary hypertension and were adjusted for 2 months under intensive medical therapy and are stable. Exclusion Criteria: * Pregnancy or lactation * Change in medication during the last 2 months * Patients with signs of right heart decompensation * severe walking disturbance * uncertain diagnoses * No previous invasively confirmation of PH * acute diseases, infections, fever * Serious lung disease with FEV1 \<50% or TLC \<70% of target * Further exclusion criteria are the following diseases: active myocarditis, unstable angina pectoris, exercise-induced ventricular arrhythmias, congestive heart failure, significant heart disease, pacemakers, and hypertrophic obstructive cardiomyopathy, or a highly reduced left ventricular function