Reduction of Sweetened Beverages and Intrahepatic Fat

University of Lausanne29 enrolled

Overview

The study will enroll 68 overweight male and female subjects with a high (\> 2 3dl-can soda/day) consumption of sweetened beverage per day. After a run-in period of 4 weeks, subjects will be randomized to either a 12-week intervention arm in which sweetened beverages will be replaced by artificially sweetened, calorie-free beverages, or to a control arm. The following measurements will be performed at the end of the run-in period and at the end of the intervention period * intrahepatic fat concentration * visceral fat volume * changes in day-long metabolic profile from baseline(plasma glucose, insulin, and triglyceride concentrations) * changes in food intake and daily energy, carbohydrate and sugars intake from baseline

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Obesity Dyslipidemia Metabolic Syndrome

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * gender male or female * body mass index (BMI) \> 27 kg/m2 consumption of \> 2 3dl-can regular soda/day * low to moderate physical activity (\< 60 min walking/day; \< 3 exercise session/week Exclusion Criteria: * diabetes mellitus * liver, kidney or heart disease * any current drug treatment * contra-indications to MR examination (pacemaker, foreign bodies,etc) * pregnancy or planned pregnancy * active weight gain or weight loss (weight change \> 4 kg in the past 12 months) * consumption of drugs or illicit substances * consumption of more than 10g alcohol/day * vegetarians or subjects on special diets

Outcomes

Primary Outcomes

changes in intrahepatic fat concentration

intrahepatic fat content measured by 1H-MRS

Time frame: at the end of run-in and after 12 weeks intervention/control

Secondary Outcomes

changes in visceral fat volume

Visceral fat volume measured by MRI

Time frame: at the end of run-in and after 12 weeks of intervention/control

changes in day-long metabolic profile

Plasma glucose, insulin, non-esterified fatty acids, and triglycerides will be measured at 2-hourly intervals between 7:00 am and 5:00 pm. Participants will be fed standardized meals and either sweetened or artificially-sweetened beverages according to randomization

Time frame: at the end of run-in and after 12 weeks of intervention/control

changes in food intake from baseline

Total energy intake, total carbohydrate intake, and total sugars intake will be evaluated by 3-day food record

Time frame: at the end of the run-in period and after 6, and 12 weeks of intervention/control