Effect of Ketamine Added to Intravenous Patient-controlled Analgesia on Postoperative Pain, Nausea and Vomiting in Patients Undergoing Lumbar Spinal Surgery

Yonsei University50 enrolled

Overview

Ketamine added to intravenous patient-controlled analgesia may be effective on prevention of postoperative nausea and vomiting by reducing opioid requirement after surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Postoperative Nausea and Vomiting

Interventions

KetamineDRUG

ketamine 3 mg/kg mixed to intravenous patient controlled analgesia device (fentanyl 20 mcg/kg. total volume 180 ml, basal infusion 2 ml, bolus 2ml, lock-out 15 min)

SalineDRUG

equal volume of normal saline mixed to intravenous patient controlled analgesia device

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Non-smoking female patients undergoing elective lumbar spinal surgery * Age 20-65 * American Society of Anesthesiologists physical status classification I or II Exclusion Criteria: * Antiemetic within 24 hrs, Taking Steroids, Opioids within 1 week * Psychiatric disease, Active drug or alcohol abuse * GI motility disorder, severe renal/ hepatic disease * insulin-dependent DM * admission to ICU after surgery

Locations (1)

Severance Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Incidence of postoperative nausea and vomiting

Time frame: within 48 hrs after surgery

Data from ClinicalTrials.gov

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