Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft

Yonsei University115 enrolled

Overview

N-acetylcysteine may prevent acute kidney injury in high risk patients undergoing off-pump coronary artery bypass graft.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

115

Conditions

Postoperative Acute Kidney Injury After Off-pump Coronary Artery Bypass Graft

Interventions

N-acetylcysteineDRUG

N-acetylcysteine 150 mg/kg bolus over 15 min after induction of anesthesia, followed by an infusion of 150 mg/kg/day for 24 hrs

SalineDRUG

Equal volume of normal saline

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing off-pump coronary artery bypass surgery and meets more than one of the following criteria; * preoperative serum creatinine \> 1.4 mg/dl * Age \> 70 years * Diabetes mellitus * left ventricular ejection fraction \< 35 % or congestive heart failure (NYHA III or IV) * emergency surgery or re-operation Exclusion Criteria: * preoperative acute renal failure, patients on dialysis, use of N-acetylcystein within 5 days of surgery, history of hypersensitivity to N-acetylcystein

Locations (1)

Severance Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Incidence of acute kidney injury

Time frame: within 5 days after surgery

Data from ClinicalTrials.gov

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