Comparison of Two Etanercept Regimens (REUMATOCEPT® Versus ENBREL®) for Treatment of Rheumatoid Arthritis

Inclusion Criteria: 1. Patients must be able to understand the study procedures agree to participate and give written consent. 2. Patients with clinical diagnosis of moderate to severe rheumatoid arthritis according to American College of Rheumatology (ACR) criteria; 3. Patients with at least 6 swollen joints 4. Patients with partial response in treatment with methotrexate for 2 months Exclusion Criteria: 1. Pregnancy and Lactation 2. Patients with uncontrolled hypertension 3. Patients with other rheumatic disease such as Sjogren syndrome, systemic lupus erythematosus or spondyloarthritis 4. Non-steroidal anti-inflammatory drug in the last 4 weeks 5. Any pathology or past medical condition that can interfere with this protocol 6. Patients with immunodeficiency and/or immunosuppressive disease; 7. Other conditions deemed reasonable by the medical investigator as to the disqualification of the individual from study participation.