A Trial Looking at Nilotinib to Treat Acral and Mucosal Melanoma Skin Cancer That Has Spread

Inclusion Criteria: 1. Patients with c-KIT mutated histologically proven advanced mucosal or acral melanoma in which the mutation is not known to be associated with nilotinib resistance. 2. Advanced mucosal and acral melanoma defined as unresectable locally advanced or metastatic disease 3. The presence of one or more clinically or radiologically measurable lesions at least 10mm in size 4. Age 18 or greater 5. ECOG performance status 0, 1 or 2 6. Life expectancy greater than 12 weeks 7. At least 14 days since any major surgery 8. The capacity to understand the patient information sheet and ability to provide written informed consent 9. Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests and other study procedures 10. Women must not be pregnant or lactating with no intention of pregnancy during study treatment. Women of child bearing potential must have a negative serum pregnancy test prior to study entry (even if surgically sterilised). Men and women of childbearing potential must use adequate birth control measures (e.g. abstinence, oral contraceptives, intrauterine device, barrier method with spermicide, implantable or injectable contraceptives or surgical sterilisation) for the duration of the study and should continue such precautions for 6 months after receiving the last study treatment 11. Serum alanine transaminase (ALT) or serum aspartate aminotransferase ≤2.5 x upper limit of normal (ULN) and total serum bilirubin ≤1.5 x ULN 12. Serum creatinine ≤1.5 x ULN 13. Serum lipase and amylase \<1.5 x ULN 14. Haemoglobin ≥9.0 g/dL, absolute neutrophil count ≥1.5 x 109/L, platelets ≥100 x 109/L 15. Prothrombin time (PT) ≤1.5 x ULN 16. Able to swallow and retain oral medication. Exclusion Criteria: 1. Intracranial disease, unless there has been radiological evidence of stable intracranial disease \> 6 months. In the case of a solitary brain metastasis, evidence of a disease-free interval of at least 3 months post surgery. All patients previously treated for brain metastases must be stable off corticosteroid therapy for at least 28 days 2. Women who are pregnant, nursing, or planning to become pregnant during the course of the trial 3. Men who plan to father a child during the course of the trial 4. Use of any investigational drug within 30 days prior to screening (both cancer and non cancer treatments) 5. Use of herbal or chinese medication 6. Use of therapeutic coumarin derivatives (ie warfarin, acenocoumarol, phenprocoumon) 7. Significant cardiac disease including patients who have or who are at significant risk of developing prolongation of QTc 8. Severe and/or uncontrolled medical disease 9. Known chronic liver disease 10. Past medical history of chronic pancreatitis 11. Known HIV infection 12. Previous radiotherapy to 25% or more of the bone marrow 13. Radiation therapy in the 4 weeks prior to study entry 14. Prior exposure to a tyrosine kinase inhibitor 15. Known lactose intolerance 16. Any malabsorption syndrome (i.e. partial gastrectomy, small bowel resection, Crohn's disease or ulcerative colitis).