Fixed Dose Rate Gemcitabine and Cisplatin Followed by Chemoradiation for Locally Advanced Pancreatic Cancer

Inclusion Criteria: * unresectable locally advanced pancreatic cancer * no distant metastasis * histologically confirmed adenocarcinoma of pancreas * 18-75 of age * ECOG performance status 0-2 * normal marrow function : * WBC at least 3,000/mm3 OR Absolute neutrophil count at least 1,500/mm3 * Platelet count at least 100,000/mm3 * normal liver function : --Bilirubin no greater than 2.0 mg/dL AST less than 3 times upper limit of normal (ULN) * normal renal function : --Creatinine no greater than 1.5 times ULN * signed informed consent