Effect of Monitoring of Pulse Index Continuous Cardiac Output (PiCCO) on Shock Patients in Intensive Care Unit

Li danyang320 enrolled

Overview

PiCCO has become a widely used haemodynamic monitoring device in the management of shock patients in ICU patients nowadays. But the effects on outcome of use of Picco, such as hospital mortality, vasoactive agents-free days, intensive care unit, and mechanical ventilation-free days and change of lactate and BNP in shock patients has not been determined. Patients will be randomly assigned to a Picco group or the control group, hospital mortality, vasoactive agents-free days, intensive care unit, and mechanical ventilation-free days and change of lactate and BNP will be observed. The conclusion will supply evidence for the clinical effectiveness of Picco in shock patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

320

Conditions

Shock

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * critically ill patients with shock: Mean arterial pressure (MAP) \< 65 mmHg (\< 8,7 kPa) or systolic arterial pressure (SAP) \< 90 mmHg (\< 12 kPa) or the need for vasopressor (Norepinephrine \<0.05µg/kg/min) to support the MAP ≥ 65 mmHg (≥ 8,7 kPa) or the SAP ≥ 90 mmHg ≥ 12 kPa), when one of these criteria has lasted for 4 hours or longer Exclusion Criteria: * Age \< 18 years * Age \> 85 years * Pregnancy (positive pregnancy test in women of child bearing age)

Outcomes

Primary Outcomes

mortality at 28 days

mortality at 28 days after diagnosis of shock

Time frame: 28 days

Secondary Outcomes

vasoactive agents-free days

vasoactive agents-free days: the number of days from day 1 to day 28 without use of vasoactive agents.

Time frame: 28 days

intensive care unit-free days

intensive care unit(ICU) free days, defined as the number of days from day 1 to day 28 without ICU stay.

Time frame: 28 days

mechanical ventilation-free days

ventilator free days: the number of days from day 1 to day 28 during which the patient breathed spontaneously

Time frame: 28 days

the change of lactate at 1,3,7 days after the insertion of the Picco catheter

blood samples will be taken before the insertion of the Picco catheter and everyday after the insertion, the change of lactate at 1,3,7 days after the insertion of the Picco catheter will be collected.

Time frame: 7 days

the change of B-Type Natruetic Peptide(BNP) at 1,3,7 days after the insertion of the Picco catheter

blood samples will be taken before the insertion of the Picco catheter and everyday after the insertion, the change of BNP at 1,3,7 days after the insertion of the Picco catheter will be collected.

Time frame: 7 days

mortality at 90 days

mortality at 90 days after diagnosis of shock

Time frame: 90 days

Effect of Monitoring of Pulse Index Continuous Cardiac Output (PiCCO) on Shock Patients in Intensive Care Unit

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts