Cellular and Humoral Immunity in Elderly After Immunization With a Japanese Encephalitis Vaccine

Medical University of Vienna60 enrolled

Overview

The aim of this project is to investigate humoral and cellular immune responses before and after immunisation with the Japanese encephalitis vaccine IXIARO in subjects above 60 years of age and 18-40 years old subjects.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Humoral and Cellular Immune Responses

Interventions

IXIAROBIOLOGICAL

2 immunizations (0,5ml) with a 28 day interval

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * adults (18-40 years old) * adults (≥60 years), * both sexes * willingness to sign written informed consent form Exclusion Criteria: * age below 18 years or between 41-59 years old * status post japanese encephalitis, tick born encephalitis (TBE), dengue, yellow fever or West Nile virus infection * previous immunization against yellow fever, japanese encephalitis (dengue or WNV) * current acute infection (body temperature above 37,9°C)

Outcomes

Primary Outcomes

cellular immunity (cytokine production upon stimulation with Japanese Encephalitis (JE) Virus Antigen) 7 days after the 2. JE-vaccination

Time frame: 7 days after the 2 JE vaccinations

Data from ClinicalTrials.gov

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