The purpose of this study is to investigate the relationship between rewarming rate during cardiopulmonary bypass and clinical prognosis in infants undergoing cardiac surgery.
There have been many studies indicating that rewarming management plays an important role in cardiac surgery. The purpose of this study is to investigate the relationship between rewarming rate during cardiopulmonary bypass and clinical prognosis in patients undergoing cardiac surgery. Infants undergoing cardiac surgery with cardiopulmonary bypass are randomly assigned to either a slow rewarming strategy (0.24 degrees C/min) or a fast rewarming strategy (0.5 degrees C/min).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
SINGLE
Enrollment
100
Rewarming rate:0.24 degrees C/min.
Rewarming rate:0.5 degrees C/min.
Xijing Hospital
Xi'an, Shannxi, China
all cause mortality
Time frame: one year
Acute renal failure
Time frame: one month
Respiratory failure
Time frame: one month
ICU and hospital length of stay, and ICU readmissions
Time frame: one month
Stroke and reversible ischemic neurologic deficit
Time frame: one month
Measures of inflammation
Measures of inflammation (C-reactive protein, TNF-alpha; IL-6) and oxidative stress markers
Time frame: one month
Biochemical markers of myocardial necrosis
Biochemical markers of myocardial necrosis（troponin and creatine kinase MB）
Time frame: one month
Perioperative complications
Perioperative complications include sternal wound infection (deep and superficial), bacteremia, pneumonia, and major cardiovascular events (acute myocardial infarction, congestive heart failure, and cardiac arrhythmias.
Time frame: one month
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