PREdictive Value of COntrast voluMe to creatinINe Clearance Ratio

Guangdong Provincial People's Hospital3,000 enrolled

Overview

To determine a relatively safe contrast media volume to creatinine clearance cut-off value to avoid contrast-induced nephropathy in patients following coronary angiography

Contrast media volume to creatinine clearance (V/CrCl) ratios were obtained from consecutive consenting patients after coronary angiography. Receiver-operator characteristic (ROC) curves were used to identify the optimal sensitivity for the observed range of V/CrCl. The predictive value of V/CrCl for the risk of contrast-induced nephropathy was assessed using multivariate logistic regression.Subgroup analysis was performed on patients with creatinine clearance \< 60 ml/min,diabetes,emergent angiography.

Study Type

OBSERVATIONAL

Enrollment

3,000

Conditions

Contrast Induced Nephropathy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients who agreed to stay in the hospital for 2-3 days after coronary angiography * provided written informed consent Exclusion Criteria: * pregnancy * lactation * intravascular administration of an contrast medium within the previous seven days * treatment with metformin,aminoglycosides,N-acetylcysteine (NAC),nonsteroidal anti-inflammatory drugs within the previous 48 h * intake of nephrotoxic drugs within the previous seven days * history of serious reactions to contrast mediums， severe concomitant disease renal transplantation , or end-stage renal disease necessitating dialysis * patients who died during coronary angiography

Locations (1)

Guangdong Cardiovascular Institute,Guangdong General Hospital

Guangzhou, Guangdong, China

Outcomes

Primary Outcomes

Contrast-Induced Nephropathy

Contrast-Induced Nephropathy was defined as an increase in serum creatinine of more than 0.5 mg/dl from the baseline within 48-72 h of contrast exposure

Time frame: 48-72 h

Secondary Outcomes

An early abnormal increase in serum creatinine

An early abnormal increase in serum creatinine defined as an increase in serum creatinine of more than 0.5 mg/dl from the baseline within 24h of contrast exposure

Time frame: 24h

Major adverse clinical events

Major adverse clinical events: death, requiring renal replacement therapy, 2nd myocardial infarction,target revascularization,acute heart failure, mechanical ventilation,2nd angina,tachyarrhythmia,hypotension,intra-aortic balloon pump and stroke

Time frame: 1 year

Major adverse clinical events

Time frame: 1month

An early abnormal increase in serum cystatin C

An early abnormal increase in serum cystatin C was defined as an increase more than 10% from the baseline within 24h of contrast exposure

Time frame: 24h

Data from ClinicalTrials.gov

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