Cerebral vasospasm(CVS) after subarachnoid hemorrhage (SAH) results in a considerable amount of transient or even permanent neurological deficits and poor outcome of the patients. Transluminal Balloon angioplasty (TBA) or intraarterial application of vasodilators represents a rescue therapy for severe CVS. Indication, duration and efficacy of this treatment, however, is still under debate. Aim of the study is to investigate if such a rescue treatment can significantly reduce new delayed ischemic cerebral deficits after SAH. Hypothesis is that the occurance of delayed infarcts can be reduced by repetetive intraarterial therapy to more than 50 %.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
92
In the invasive arm CVS should be treated by intraarterial therapy and efficacy controlled by CT or MRI after 48 hours and if necessary repeated.
Neurochirurgische Klinik, Universitätsklinik
Düsseldorf, Germany
ACTIVE_NOT_RECRUITINGDepartment of Neurosurgery, Johann Wolfgang Goethe-University
Frankfurt am Main, Germany
RECRUITINGNeurochirurgische Klinik der Universität Ulm
Günzburg, Germany
RECRUITINGKlinik für Neurochirurgie, Universitätsklinikum
Jena, Germany
RECRUITINGKlinik für Neurochirurgie, Universitätsklinikum
Mannheim, Germany
ACTIVE_NOT_RECRUITINGNew infarcts between baseline and final MRI
Time frame: 21 + - 7 days
Clinical outcome (mRS, Karnofsky)
Time frame: 6 months
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