Beta-glucans are polysaccharides consisting of glucose residue jointed by beta linkage. They are found at a high level in the cell wall of fungi, yeast, oat, barley, bacteria, as well as various mushroom. Studies have reported that extract of mushroom (Pleurotus eryngii) can prevent the bone loss caused by estrogen deficiency. Furthermore, polycan (a purified β-glucan from Aureobasidium pullulans) has been reported to exhibit osteoporosis preventing effects. However, no investigation has been conducted on the effect of polycan on bone health in perimenopausal women. Therefore, in this study, we investigated the effect of polycan on biochemical markers of bone metabolism in Korean perimenopausal women.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
60
polycan 150 mg/d for 12 weeks
Placebo 150mg/d for 12 weeks
Healthcare claims and management; Chonbuk National university
Jeonju, Jeollabuk-do, South Korea
Changes in DPD(Deoxypyridinoline)
DPD(Deoxypyridinoline) was measured in study visit 1(0 week) and visit 3(12 week).
Time frame: 12weeks
Changes in OSC(Osteocalcin)
OSC(Osteocalcin) was measured in study visit 1(0 week) and visit 3(12 week).
Time frame: 12weeks
Changes in CTx(Collagen Type 1 Cross-linked C-telopeptide)
CTx(collagen type 1 cross-linked C-telopeptide) was measured in study visit 1(0 week) and visit 3(12 week).
Time frame: 12weeks
Changes in bALP(Bone-specific Alkaline Phosphatase)
bALP(bone-specific alkaline phosphatase) was measured in study visit 1(0 week) and visit 3(12 week).
Time frame: 12weeks
Changes in PTH(Parathyroid Hormone)
PTH(parathyroid hormone) was measured in study visit 1(0 week) and visit 3(12 week).
Time frame: 12weeks
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